Blocking this interaction also has proven therapeutic potential to prevent malaria, with antibodies against both PfRH5 and basigin identified which inhibit invasion (Alanine et al., 2019; Douglas et al., 2014; Wright et al., 2014; Zenonos et al., 2015), with vaccination (Douglas et al., 2015) or passive transfer of neutralising antibodies (Douglas et al., 2019) leading to protection of Aotus monkeys from parasite challenge and with human vaccination slowing the onset of parasitaemia (Minassian et al., 2021). This evidence concerns the gene BSG and malaria.