NOTCH1 and cancer: We observed higher levels in younger African American patients of MYC and NOTCH1, 2 genes that are well known for their relevance in cancer.29,30,31,32 Clinically, efforts are being made to develop anti-NOTCH targeted therapies, primarily through the use of γ-secretase inhibitors and monoclonal antibodies against Notch receptors.33 Younger African American patients with TNBC showing disproportionate enhancement of NOTCH1 could potentially benefit from these novel therapies.