PLEKHM1 and aortic stenosis: By suppressing pleckstrin homology and RUN domain containing M1 (PlekhM1), cardiomyocyte autophagy is prevented, and hypertrophy is induced by Chast. Chast has a homologous sequence in humans and the human form is also upregulated in patients with aortic stenosis that drives cellular hypertrophy [41].