ATM and chronic kidney disease: While there were some variations between the parental, ATPTG8Ty/cKD, and ATPTG9Ty/cKD strains upon treatment with vehicle control, there was a significant decrease in cristae density when ATc was added to ATPTG8Ty/cKD or ATPTG9Ty/cKD parasites for 72 h (Fig. 4A and B).