4 The thioredoxin system plays a vital role in sustaining cellular redox balance and enabling cancer cells to escape ferroptosis.133 Comprised of NADPH, thioredoxin reductase (TrxR), and thioredoxin (Trx), this system compensates for the absence of GSH biosynthesis in keratinocytes by the collaborative action of the SLC7A11 and the thioredoxin system.134 In this process, the transfer of electrons from NADPH to oxidized Trx by TrxR results in the conversion of oxidized Trx to its reduced dithiol form. This evidence concerns the gene TXN and cancer.