To compare the performance of CRRS with other coagulation‐related signatures, we comprehensively retrieved published signatures, including Jin's model with 11 signatures (SERPINA1, CFHR3, PPP1CB, P2RX1, PLCB3, PLCB4, PIK3R6, GP6, PIK3R1, GP1BA, PLA2G4F) in HCC,17 Chen's model with seven signatures (SERPINE1, VWF, F2R, ANXA5, CD59, AXL, MMRN1) in gastric cancer,25 Jia's model with four signatures (SERPINA1, HMGCS2, MMP7, PLAT) in invasive ductal cancer,26 Song's model with seven signatures (ANG, C1QA, CFB, DUSP6, KLKB1, MMP7, RABIF) in melanoma.5 This evidence concerns the gene HMGCS2 and hepatocellular carcinoma.