F2R and hepatocellular carcinoma: To compare the performance of CRRS with other coagulation‐related signatures, we comprehensively retrieved published signatures, including Jin's model with 11 signatures (SERPINA1, CFHR3, PPP1CB, P2RX1, PLCB3, PLCB4, PIK3R6, GP6, PIK3R1, GP1BA, PLA2G4F) in HCC,17 Chen's model with seven signatures (SERPINE1, VWF, F2R, ANXA5, CD59, AXL, MMRN1) in gastric cancer,25 Jia's model with four signatures (SERPINA1, HMGCS2, MMP7, PLAT) in invasive ductal cancer,26 Song's model with seven signatures (ANG, C1QA, CFB, DUSP6, KLKB1, MMP7, RABIF) in melanoma.5