PTGFRN and esophageal squamous cell carcinoma: Based on the results of Venice criteria, FPRP, and BDFP, the reliability of epidemiological evidence for the significant association between rs671 and the risk of ESCC was upgraded from moderate to strong, the association between rs1229984 and ESCC risk was upgraded from weak to moderate, and the evidence remained weak for rs1042026 and rs674.