Therefore, high VND of TPSO PET radiotracers can significantly impact quantification of TSPO changes in different brain diseases limiting their sensitivity.19 Outcome measures derived using a TSPO PET radiotracer with low VND and insensitivity to the rs6971 polymorphism would potentially be transformative to the field by enabling accurate quantification of TSPO with greater sensitivity, thus allowing early detection of neuroinflammation and more subtle physiological changes in TPSO expression, such as during natural aging or as a result of subject’s biological sex. The gene discussed is TSPO; the disease is brain disorder.