ANGPTL4 and hypertriglyceridemia: Of the nearly 40 differentially expressed genes noted, an unknown downregulated gene, subsequently cloned and identified as transcriptional factor zinc finger and homeoboxes 3 (Zhx3) (7), and a highly upregulated gene, angiopoietin-like 4 (Angptl4) (9), previously known to be involved in pathogenesis of hypertriglyceridemia, were investigated.