Circulating ANGPTL4 also induces hypertriglyceridemia via lipoprotein lipase inhibition, and studies in rat models of diabetic nephropathy using injection of recombinant-mutated human ANGPTL4 have suggested that the antiproteinuric effect occurs at a lower dose than the hypertriglyceridemic effect (10). This evidence concerns the gene ANGPTL4 and diabetic kidney disease.