CD4 and Opportunistic infection: Risk factors for delirium include the presence of neurocognitive impairment as well as acute and opportunistic infections, which more commonly occur with advanced immunosuppression.30 In contrast, multiple studies have found that markers of advanced HIV such as lower CD4 counts were not a significant risk factor for delirium.30 The results support early initiation of ART to assist with various degrees of neurocognitive impairment.