Further multivariate logistic regression by including variables with a univariate P value< 0.05 showed that CTR (odds ratio [OR] = 0.081; 95% confidence interval [CI]: 0.043–0.147; P< 0.001), calcification (yes vs. no; OR = 0.050; 95% CI: 0.005–0.355; P = 0.006), age (OR = 1.025; 95% CI: 1.005–1.046; P = 0.013), maximum tumor diameter (OR = 3.927; 95% CI: 2.192–7.204; P< 0.001), CEA (OR = 1.265; 95% CI: 1.057–1.556; P = 0.018), and nodule shape (regularity vs. irregularity; OR = 1.577; 95% CI: 1.013–2.470; P = 0.045) were risk factors. This evidence concerns the gene CEACAM5 and neoplasm.