These types of alternative splicing upon PRMT5 downregulation in breast cancer cell line MDA-MB-231 were found to be enriched for transcription products associated with RNA processing such as splicing genes- HNRNPC, HNRNPH1, RBM5, RBM23, RBM39 and U2AF1 (56). The gene discussed is PRMT5; the disease is breast carcinoma.