The synaptic efficiency of trigeminal neurons is established through long-term potentiation, which uses molecules that proliferate dendritic growth to strengthen associations between neuronal activity and headache pathology; one of these molecules, brain-derived neurotropic factor (BDNF), is released by a neurogenic inflammatory neuropeptide called calcitonin gene-related peptide (CGRP). The gene discussed is BDNF; the disease is Headache.