AR and migraine disorder: The efficacy of testosterone in reducing headache pain implies that testosterone could participate in the same processes as progesterone to reverse estrogen-mediated pronociception; Since both ovarian hormones lower the availability of serum 5-HT in migraine patients, testosterone could bolster the efficacy of serotonin binding by regulating 5-HT receptor expression through the colocalization of AR with 5-HT2 receptors.