Elevated levels of LCETRL3 or LCETRL4 in NSCLC cells lead to inhibition of ubiquitination of TDP43 or EIF2S1, which thereby enhances the stability of proteins TDP43 or EIF2S1, and leads to resistance to tyrosine kinase inhibitors of epidermal growth factor receptor (EGFR) (99). This evidence concerns the gene TARDBP and non-small cell lung carcinoma.