The results of univariate cox regression analysis (Table 4) showed that diabetes, age, female, chronic renal disease, heart rate, fasting blood glucose, HbA1c, TNI, WBC count, BNP, serum creatinine, revascularization, β-receptor blocker, ACEI/ARB/ARNI were important risk factors of CR (P<0.05). This evidence concerns the gene NPPB and diabetes mellitus.