There were significant differences between the two groups in age, female ratio, BMI, rates of current smoker, peripheral artery disease, heart rate, systolic blood pressure, diastolic blod pressure, fasting blood glucose, HbA1c, hemoglobin, serum creatinine, TNI, BNP, Gensini score, LVEF, LVESd, LVEDd, revascularization rate and the application rate of NOAC, β-receptor blocker, ACEI/ARB/ARNI and statin (all P<0.05). This evidence concerns the gene NPPB and peripheral arterial disease.