Furthermore, in a study conducted by Lavinia Raimondi et al., pre-osteoclast cells (pOCs) were treated with MM cell-derived small extracellular vesicles (MM-EVs), revealing an increased expression of XBP1 in pOCs after 3 days of treatment with MM-EVs compared to untreated cells. This evidence concerns the gene XBP1 and Miyoshi myopathy.