CD8A and neoplasm: As shown in a syngeneic mouse model with TRAMP-C2 tumors grown in C57BL/6J mice, PLMDs plus RT increased the recruitment of antitumor immune cells, CD8+ T cells, and M1 macrophages while lowering the percentage of immunosuppressive cells, regulatory T cells (Tregs), and MDSCs within the tumor, resulting in increased apoptosis, slowed tumor growth, and prolonged host survival.