Additionally, Aβ and tau suppressive activity of Hsp70 has been shown to be abolished in the presence of ε4 isoform of apolipoprotein E (ApoE), one of the most recognizable factors contributing to AD (Osorio et al., 2007; Serrano-Pozo et al., 2021). The gene discussed is HSPA1A; the disease is Alzheimer disease.