Although several studies in breast cancer cells have shown that calpain activation and mitochondrial dysfunction are key mechanisms for the cytotoxicity of different pharmacological anticancer drugs (Tagliarino et al., 2003; Cui et al., 2007; Sareen et al., 2007; Sobhan et al., 2013; Al-Bahlani et al., 2017; Ciscato et al., 2020), calpain activity has also been implicated in the pro-survival activity of NFкB or p53 in cancer cells (Pianetti et al., 2001; Pozo-Guisado et al., 2005; Fei et al., 2013). Here, TP53 is linked to breast carcinoma.