However, it seems that alternative mechanisms to disrupt E-cadherin function must contribute to the invasive phenotype; a fraction of patients with invasive lobular carcinoma retain E-cadherin expression and 50% of patients showing loss of E-cadherin do not have CDH1 inactivating mutations (Bruner and Derksen, 2018). Here, CDH1 is linked to invasive lobular breast carcinoma.