In addition, this study identified association of CD4 and CD8 T cell emergence in case of progression towards more severe COVID-19, as well as multiple proteome-level changes, such as RAS, lung homeostasis and hemostasis pathways enrichment, and cytokine storm elements, such as increased plasma levels of IL1B, IL-33, IL-6, and IFNγ. The gene discussed is CD8A; the disease is COVID-19.