However, there are some reports of PCA2 (microtubule-associated protein 1B) (15), ANNA2 (anti-Ri) (16), Ma2 (17), or ANNA1IgG (7) seropositivity with non-small cell lung cancer that include adenocarcinoma, even though these associations are not as well characterized as ANNA1 IgG and SCLC (18) or KLHL11 IgG and testicular germ cell tumor (3, 12). This evidence concerns the gene PNMA2 and adenocarcinoma.