Moreover, the cytotoxicity was also indicated by independent experiments using MTT assay, the result demonstrated the dramatically diminished metabolic activities in both PCa cell lines DU-145 (PSMA-) and LNCaP C4-2 (PSMA+) after exposure to 223RaA-silane-PEG-D2B compared to that treated with non-223Ra labeled, bio-conjugated-NaA-silane-PEG-D2223. Here, FOLH1 is linked to posterior cortical atrophy.