When we analyzed the PD-1+ LAG-3+ CD8 TCM and TEM subsets as a proportion of the total tumor infiltrating CD8 T cells, we found that the double positive TEM cells constituted a sizeable minority of the population, with a median frequency of 14.0% (range = 4.1% – 42.1%; Figure 3B). Here, LAG3 is linked to neoplasm.