This double positive subset was found in 4/28 TIL samples from CD8 CM cells (2/9 endometrial and 2/2 melanoma), and 20/28 TIL samples from the CD8 EM cells (7/10 colon, 8/9 endometrial, 2/4 kidney, 1/1 lung, and 2/2 melanoma). The gene discussed is CD8A; the disease is melanoma.