However, T cell subsets among TIL samples showed an expected enrichment of the median frequency of CD4 TEM cells (19.7% vs. 10.6 - 10.8%), CD8 TEM cells (24.0% vs. 5.4 - 7.4%), and Tregs (8.9% vs. 1.7 - 2.5%), and reduction of naïve T cells (0.9% vs. 18.3 - 38.4%; Supplementary Figure 5B) compared to peripheral T cells from heathy donors and cancer patients. This evidence concerns the gene CD4 and cancer.