Depletion of Flot2 demonstrated its essential role in CD44 expression, but its absence affects the cytoskeleton, polarity, and homing defects, as well as the progression of chronic myeloid leukemia (CML), while acute myeloid leukemia (AML) remains unaffected (140). Here, FLOT2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.