CD4 and acute myeloid leukemia: RNAseq analysis before antigen recognition revealed that CAR-T cells from AML patients were transcriptionally similar to those from senior healthy donors, with only a few differentially expressed genes (DEGs) with an FDR<0.05 and a |log2FC|>1 (31 for CD4+ and 12 for CD8+ CAR-T cells) (Table S6).