NPHS1 and focal segmental glomerulosclerosis: So far murine models transgenic for slit diaphragm and cytoskeleton of the foot process protein genes, such as NPHS1 (255, 256), NPHS2 (257, 258), αACT4 (259, 260), CD2AP (261), TRPC6 (262), PODXL (263) are available and provided invaluable insights into the function of the single protein and the role of its abnormality in the pathogenesis of proteinuria and FSGS development in the genetic forms of the disease.