F10 and stroke disorder: Long-term aspirin at doses greater than 100mg per day (increased risk of bleeding, no evidence for increased efficacy) Antiplatelet agents, vitamin K antagonists, direct thrombin inhibitors or factor Xa inhibitors with concurrent significant risk of major bleeding. Aspirin plus clopidogrel as long-term secondary stroke prevention i.e., > 4 weeks, (no evidence of added long-term benefit over clopidogrel monotherapy).