HLA-C and toxic epidermal necrolysis: In the subgroup analysis, the frequencies of patients who carried HLA alleles, including HLA-A*02:06, HLA-A*03:02, HLA-B*57:01, HLA-B*46:02, HLA-C*06:02, and HLA-DQB1*03:02, were significantly higher in the SJS/TEN group compared with the control group (p < 0.05) (Table 3).