Therefore, subgroup analysis based on SCARs phenotypes was performed in the present study, and the results showed that six HLA alleles including HLA-A*02:06, HLA-A*03:02, HLA-B*57:01, HLA-B*46:02, HLA-C*06:02, and HLA-DQB1*03:02, were associated with SJS/TEN. The gene discussed is HLA-B; the disease is toxic epidermal necrolysis.