The mutated proto-oncogene B-Raf (BRAF) negatively modulates oxidative metabolism in the cancer cells of MM (Haq et al., 2013), while BRAF inhibitors (BRAFi) increase the dependence of melanoma cells on oxidative phosphorylation (OXPHOS) (Haq et al., 2013; Schöckel et al., 2015). This evidence concerns the gene BRAF and cancer.