CHAC1 and Miyoshi myopathy: Nrf2 is efficiently activated in resistant MM cells, leading to upregulation of the early ferroptosis marker ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) and the aldo-keto reductase AKR1C1 ÷ 3 that degrades 12/15-LOX-mediated production of lipid peroxides to induce ferroptosis resistance.