In 2016, Allam et al. conducted a study to investigate the ellagic acid potential effect on the adjuvant induced arthritis (AIA) model in mice and found that supplemenation of 700 mg/kg body weight of ellagic acid let to an increase in IFNγ levels, while TGF-β levels did not change (47). This evidence concerns the gene TGFB1 and arthritic joint disease.