TNF and colon carcinoma: In one study, ellagic acid effects at doses of 5, 10, and 20 μg/mL on the immunologic balance of mononuclear cells and colon carcinoma cells were investigated, which at high doses the production of IL-6, TNF-α, IL-1, and IL-10 cytokines suppressed, while showing no effect on IFNγ (46).