INS and polycystic ovary syndrome: According to the research of Javanmanesh et al., in compare to metformin, receiving NAC at a dose of 1800 mg per day for 6 months decreased the level of FBS, insulin, HOMA-IR, and serum TG in women with polycystic ovary syndrome (PCOS), but it had no effect on their other lipid profiles (34).