On the other hand, TIS21/BTG2/PC3 can inhibit the degradation of cyclin A and cyclin B1 in G2/M phase when stimulated by epidermal growth factor (EGF) at high concentration, and directly combine with Cdc2, thus hindering cell mitosis and increasing the aging and death of tumor cells15. The gene discussed is CCNB1; the disease is neoplasm.