In 2016, Tang et al.14 found that the expression of anti-aging gene Klotho increased in patients with liver cancer, which inhibited Wnt/β-catenin signaling pathway, decreased the expression of β-catenin, inhibited the transport of β-catenin from cytoplasm to nucleus, and decreased the expression of two known target genes c-myc and CyclinD1 in Wnt/β-catenin pathway14. The gene discussed is CCND1; the disease is liver cancer.