The results showed that 14 core targets TP53, JUN, CASP3, HSP90AA1, VEGFA, HRAS, CDH1, MAPK3, PPARG, CDKN1A, SRC, CYCS, BCL2L1 and CDK4 were significantly associated with poor prognosis in GC (p < 0.05). Here, CASP3 is linked to gastric cancer.