The PI3K/AKT signalling pathway is an important growth regulatory pathway that regulates multiple physiological functions, including cell proliferation, differentiation, cell metabolism, apoptosis and cancer cell survival77; it has become a hot spot for tumour molecular marker‐targeted therapy,78, 79 more and more evidence80, 81 that the PI3K/Akt pathway is frequently activated in GC and is directly related to the occurrence and development of GC, and inhibition of the PI3K/Akt signalling pathway has been used as a therapeutic strategy for the treatment of GC patients. The gene discussed is AKT1; the disease is cancer.