Based on the results of ROC curve and KM survival analysis, we predicted that 13 key targets TP53, JUN, CASP3, HSP90AA1, VEGFA, HRAS, CDH1, MAPK3, CDKN1A, SRC, CYCS, BCL2L1 and CDK4 may be the key targets of EA against GC. The gene discussed is CDK4; the disease is gastric cancer.