The results showed that 14 core targets TP53, JUN, CASP3, HSP90AA1, VEGFA, HRAS, CDH1, MAPK3, PPARG, CDKN1A, SRC, CYCS, BCL2L1 and CDK4 were significantly associated with poor prognosis in GC (p < 0.05). The gene discussed is CDKN1A; the disease is gastric cancer.