ALX4 and colorectal carcinoma: Methylated markers such as BCAT1 and IKZF1 [34], C9orf50, KCNQ5, and CLIP4 [35], SFRP2 and SDC2 [36], cg10673833 [37], APC, MGMT, RASSF2A, and Wif-1 [38], ALX4, BMP3, NPTX2, RARB, SDC2 and VIM [39], and NEUROG1 [40] have reported sensitivities ranging from 66–91% for CRC detection and 5–58% for premalignant AA, with 73–99% specificity.