For further mechanistic insights into the role of B7-H4 in breast cancer cell chemoresistance, the chemosensitivity of Doxorubicin [30], Oxaliplatin [31, 32], Fluorouracil [33] and Gefitinib [34] was investigated in B7-H4-KO and B7-H4-OE cells by evaluating the IC50 values. This evidence concerns the gene VTCN1 and breast carcinoma.