Survival analysis stratified by cancer type in TCGA dataset revealed that there was a significant association between the frequency of NFE2L2 MU and shorter OS in LGG (HR: 7.43, 95% CI 1.81–30.38) and LUAD (HR: 2.31, 95% CI 1.25–4.27; Additional file 1: Fig. S4A, Fig. 4A). Here, NFE2L2 is linked to cancer.