Given the interaction of NFE2L2 with KEAP1 via the DLG and ETGE motifs [11], it was found that the prevalence of Nrf2-activating mutation (MU) was higher than that of Nrf2-inactivating mutation (MU) in the majority of cancer types (Fig. 2D and Additional file 1: Fig. S2A). Here, NFE2L2 is linked to cancer.