Pathology-specific AD1–microglia subgroups localized to Aβ and AD2–microglia subgroups associated with p-tau [73], as well as temporally specific early stage AD-associated microglia (EADAMs) and late-stage AD-associated microglia (LADAMs) [74], were identified by distinct genetic and functional signatures. The gene discussed is CD63; the disease is Alzheimer disease.