The genes most strongly downregulated in the GF placenta (Fig. 4E) included immunoglobulin and complement genes, the recently characterized bacterial response gene AW112010, the interleukin receptor Il1r2 implicated in endometriosis, the diamine oxidase Aoc1 implicated in pregnancy regulation, the prolactin precursor Prl3d1, the exosomal endonuclease Endod1, the neuroendocrine peptide Gal, the mitogen Mdk, the mitochondrial pyruvate dehydrogenase kinase Pdk4, and the lncRNAs Gm7932 and 4933417E11Rik. This evidence concerns the gene PDK4 and endometriosis.