TARDBP and early-onset autosomal dominant Alzheimer disease: In addition, TDP-43 is the main cause of a recently recognized disease entity, the limbic-predominant age-related TDP-43 encephalopathy (LATE) that seems to share some pathogenic mechanisms with both frontotemporal lobar degeneration with TDP-43 and Alzheimer’s disease, while also showing disease-specific underlying mechanisms [46].