Therefore, in this study, it was investigated the association between eight INDEL variants in apoptosis-related genes (FAS, FADD, CASP8, BCL-2, CASP9, CASP3, and TP53), and the infection by P. falciparum, P. vivax, and mixed infection, focusing on susceptibility to infection and parasite density. This evidence concerns the gene CASP3 and infection.