By searching the 18 candidate hub genes in GeneCards database, we found that CAV1 and PECAM1 were specifically expressed in lung tissues, BMP4 and VEGFA were related to angiogenesis, FYN and SPP1 were related to immunity or inflammation, and COL1A1 was closely associated with pulmonary fibrosis. The gene discussed is SPP1; the disease is pulmonary fibrosis.