SOX2 and cancer: Elevated nuclear KJC8 scores and KJC133 scores, may be reflecting elevated Δ133p53β expression, which has not only been previously linked to worse prognosis in melanoma [35], but may be driving dedifferentiation of melanoma cells into cancer stem cell through the upregulation of pluripotency genes such as SOX2, NANOG, and OCT3/4 [36].