Nuclear p53β:TAp53 ratios (KJC8/DO-1) negatively correlated with Breslow thickness (Spearman’s rho: -0.369, p < 0.001) (Table 1); overall, suggesting that while elevated nuclear Δ40p53 detection and p53β:TAp53 ratio (KJC8/DO-1) are associated with better prognostic features, elevated nuclear TAp53 isoforms are associated with more aggressive melanoma, corroborating evidence that dysregulated wild-type p53 may function as an oncogene in melanoma [4, 6]. The gene discussed is TP53; the disease is melanoma.