Variables such as lactate level (P for interaction = 0.004), phenylephrine use (P for interaction = 0.008), receipt of RRT (P for interaction = 0.038), and presence of renal disease (P for interaction = 0.027) demonstrated an interaction between albumin-adjusted AG and 28-day ICU mortality in Model I. Additionally, variables such as temperature (P for interaction = 0.03), APS III (P for interaction = 0.048), and presence of chronic pulmonary disease (P for interaction = 0.002) demonstrated a similar interaction. The gene discussed is ALB; the disease is kidney disorder.