In the case of Alzheimer’s disease (n = 389 cases in Iceland and n = 224 cases in UKB-BI), neurofilament light (NFL) (encoded by NEFL) was targeted on both platforms and strongly associated with disease on both (rank 2 of all assays on Olink and rank 3 of all assays on SomaScan based on effect and significance), but with opposite direction (UKB-BI Olink: OR = 1.64 per s.d., P = 1.3 × 10−12; SomaScan OR = 0.53 per s.d., P = 9.7 × 10−52). The gene discussed is NEFL; the disease is early-onset autosomal dominant Alzheimer disease.