The large number of important immune signalling pathways that are enhanced by inhibition of PTPN2/N1, including IFN sensing, TCR signalling and IL-2, IL-7 and IL-15 signalling suggest that AC484 can work to stimulate immune responses through a variety of cellular and molecular mechanisms to exert its anti-tumour activity. The gene discussed is PTPN2; the disease is neoplasm.