The use of 8 simple clinical features in the logistic regression model based MODY risk calculator distinguished the 3 common monogenic diabetes subtypes GCK, HNF1A, HNF4A collectively from Type 1 diabetes or Type 2 diabetes with a c-statistic of 0.98 and 0.95 respectively. This evidence concerns the gene HNF4A and type 2 diabetes mellitus.