The genetic diagnosis of any given monogenic diabetes subtype informs precision prognostics e.g., lack of microvascular or macrovascular complications in those with a heterozygous GCK etiology and informs precision monitoring particularly in syndromic forms where the genetic diagnosis precedes the development of additional clinical features such as hepatic dysfunction and skeletal dysplasia in EIF2AK3 or hearing and vision loss in WFS18,9. Here, GCK is linked to diabetes mellitus.