As these changes match the pattern of RhoB expression and activity—downregulation of RhoB promotes cell migration and invasive behaviour [21, 22], and we demonstrate a direct correlation between RhoB and S100PBP expression in both PDAC and CML cells, this indicates that S100PBP plays an important role in modulating cytoskeleton, cell morphology, motility and invasion via RhoB signalling. The gene discussed is RHOB; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.