Mutant KRAS is known regulator of various S100 proteins in many cancers [10, 11], and is an earliest driver of PDAC development; we thus wanted to establish if mutant KRAS plays a role in modulating the expression of S100PBP, especially since total KRAS levels remained largely unchanged after stable expression of S100PBP in CFPac1 and PaTu-8988t cells (Supplementary Fig. 3b). This evidence concerns the gene S100PBP and cancer.