This was verified in vitro in CML and several PDAC cell lines: the S100PBP protein was highly expressed in Panc1, MIA PaCa-2 and HAP1-parental cells, which also showed elevated expression of RhoB, p-myosin phosphatase1 (MYPT1)-S696 and p-cofilin-S3, indicating an active RhoB/Rho-kinase (ROCK) signalling (Fig. 1C). This evidence concerns the gene RHOB and chronic myelogenous leukemia, BCR-ABL1 positive.