INSR and generalized lipodystrophy: Individuals reported in the studies included 90 with partial lipodystrophy (72 due to LMNA mutation and 15 due to PPARG mutation), 42 with generalized lipodystrophy (21 AGPAT2, 21 BSCL2, 2 LMNA), and 19 with IR due to INSR mutation(s).