Biomarkers including serum C-reactive protein (CRP) (− 70%), serum insulin (− 73%), serum glucose (− 13%), the homeostatic model assessment of insulin resistance (HOMA-IR) (− 77%), and serum triglycerides (− 47%), but not total serum cholesterol or LDL-cholesterol, were significantly lower in LIFE versus CON (all p < 0.001) (Table 1). The gene discussed is INS; the disease is Insulin resistance.