While HER2 IHC 1 + showed no significant difference in HR of DFS (HR = 0.99, 95% CI 0.73–1.35) compared to HER2-negative, HER2 IHC2 + /ISH-BC had significantly lower HR for DFS (HR = 0.12, 95% CI 0.02–0.84) compared to HER2-negative group (Table 2). The gene discussed is ERBB2; the disease is breast cancer.